Antihyperglycemic effects of Amrtottara Kvatha, an Ayurvedic polyherbal formulation in streptozotocin-induced diabetic rats by suppressing oxidative stress

Amrtottara Kvatha [KNM3] (AK) is a widely used Ayurvedic preparation, primarily utilized for hyperpyrexia (‘Jwara’). In the present study we evaluated antidiabetic effect of AK against streptozotocin (STZ) induced diabetic murine model. The effects on normoglycemic rats and glucose tolerance were also studied. was in (STZ, 55 mg/kg, i.p.) rats. administered orally at four doses (1/4), (1/2), (T) (DD) fourteen days to examine activity with glibenclamide (5 mg/kg) as reference standard. blood insulin levels, biochemical parameters, oxidative stress biomarkers histopathological examinations Oral administration diabetes showed significant (P<0.01) decrease levels improved liver glycogen pancreatic protein content. (malondialdehyde advanced oxidation products) reduced all treated groups increase antioxidant enzyme status. Histopathological studies supported findings. reports first time by suppressing Wistar